Effect of Magnesium Sulphate on Attenuation of Hemodynamic Stress Responses during Laparoscopic Abdominal Surgeries

Introduction: This randomized, double-blind, prospective study was undertaken to evaluate the effect of magnesium sulphate in attenuating the stress responses associated with laparoscopic abdominal surgeries. Methods: 62 patients who underwent laparoscopic abdominal surgery were randomly divided in to two groups, group I and group II. 5 minutes after intubation but before creation of pneumoperitoneum, the magnesium group (group I) received magnesium sulphate 50 mg/kg diluted in normal saline to total volume of 20 ml at 240 ml/hour over 5 minutes. The control group (group II) received same amount of normal saline. Results: Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure were significantly less in group I with p<0.05. Train of four had no statistical significance. Extubation time was more in Group I but had no statistical significance. Conclusion: magnesium sulphate attenuates hemodynamic stress response in laparoscopic abdominal surgeries.